San Francisco’s cruise terminal became a public health flashpoint Thursday as the Ruby Princess, operated by Princess Cruises, arrived at Pier 27 with a confirmed norovirus outbreak. The U.S. Centers for Disease Control and Prevention reported that 102 of the more than 3,000 passengers and 23 crew members have fallen ill during the 20-day voyage that began June 12.

Symptoms—primarily diarrhea and vomiting—emerged over the weekend, triggering a rapid response from the cruise line and federal health authorities. The CDC’s Vessel Sanitation Program is remotely tracking the situation and reviewing the ship’s containment measures.

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Princess Cruises acknowledged the outbreak in a statement to Nexstar affiliate KRON4, describing it as “a limited number of guests” who reported “mild gastrointestinal illness.” The company said crew members acted quickly by deploying enhanced sanitation protocols across the vessel.

According to the CDC, the ship’s response includes stepped-up cleaning and disinfection, stool sample collection from affected individuals for lab testing, isolation of sick passengers and crew, and direct consultation with the Vessel Sanitation Program. The outbreak was officially logged on Saturday.

The Ruby Princess is now undergoing a “comprehensive cleaning and disinfection,” the cruise line confirmed, as passengers disembark in San Francisco. The vessel had been at sea for nearly three weeks before the outbreak peaked.

Norovirus outbreaks on cruise ships are a recurring public health challenge, often spreading quickly in confined environments. The CDC notes that norovirus is highly contagious and can survive on surfaces for days. This incident comes amid a broader scrutiny of disease containment on passenger ships.

In related news, the CDC is also tracking a seasonal cyclospora outbreak that has surpassed 315 cases, underscoring the agency’s ongoing battle with gastrointestinal illnesses. Meanwhile, a listeria outbreak linked to soft cheese has killed one and hospitalized eight across three states, highlighting the persistent risks in foodborne and travel-related contagions.

Public health experts emphasize that norovirus outbreaks are often underreported, but the CDC’s involvement ensures transparency and accountability. The Ruby Princess is expected to depart after sanitation is completed, with the cruise line pledging full cooperation with federal guidelines.