Sen. Rand Paul (R-Ky.) voiced surprise Wednesday that Dr. Anthony Fauci chose to plead the Fifth Amendment during a Senate hearing, despite receiving what Paul described as an unusually sweeping preemptive pardon from former President Joe Biden.

In an interview with NewsNation's Katie Pavlich, Paul noted that Fauci's pardon—covering any potential offenses tied to his government work from 2014 through January 2025—should have made the Fifth Amendment unnecessary. “I was kind of surprised,” Paul said. “He’s been granted a very broad pardon, a 10-year pardon. The only person I know of in history who’s gotten a pardon this broad has been Hunter Biden—maybe not the best category or company to keep.”

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The heated hearing, which focused on the origins of the COVID-19 pandemic and Fauci's role in gain-of-function research, saw the former White House chief medical adviser invoke his right against self-incrimination repeatedly. According to a separate report, Fauci actually pleaded the Fifth 111 times during the session, a move that has now set up a potential contempt vote before a Senate panel next week.

Paul, who chairs the Senate Homeland Security and Governmental Affairs Committee, released more than 1,000 pages of Fauci's personal diaries ahead of the hearing. The Kentucky Republican argued that the preemptive pardon from Biden effectively nullified Fauci's ability to claim Fifth Amendment protection, since he could no longer face criminal liability for any related offenses. “We believe that with his immunity from criminal liability, he didn’t need to hide behind the Fifth Amendment,” Paul told reporters after the hearing. “Maybe the Fifth Amendment doesn’t attach when you have a pardon in place. That’ll be a legal question.”

The clash between Paul and Fauci is the latest chapter in a long-running feud. The GOP senator has repeatedly pressed Fauci on the possibility that the coronavirus originated from a lab leak in China, accusing the former health official of covering up U.S. involvement. During Wednesday's hearing, one of Fauci's attorneys was escorted out after attempting to speak, and the doctor himself remained largely silent, citing his Fifth Amendment rights.

Paul's push for a contempt referral is complicated by the pardon's scope, but he indicated he plans to move forward regardless. The pardon and Fifth Amendment clash has already set up a contempt vote, and Paul is expected to refer the matter to the full Senate. Meanwhile, the Florida attorney general has launched a separate probe into Fauci's conduct during the pandemic, adding further legal pressure.

Democrats on the committee accused Paul of conducting a partisan vendetta, with Sen. Gary Peters (D-Mich.) condemning the hearing as a political spectacle. But Paul and his allies argue that Fauci's silence, even under the protection of a pardon, raises serious questions about accountability for pandemic-era decisions.

The Biden administration's decision to grant Fauci such a broad pardon has drawn criticism from both sides. Former President Donald Trump, who has also weighed in, endorsed the pardon but questioned whether it was properly signed. As the legal and political battles intensify, Fauci's Fifth Amendment gambit may ultimately test the limits of executive clemency and legislative oversight.