Iran's Supreme Leader Mojtaba Khamenei on Saturday declared President Trump's signature on the U.S.-Iran ceasefire memorandum of understanding to be “utterly worthless and devoid of credibility,” accusing Washington of repeatedly violating the agreement as American airstrikes continued for a seventh consecutive night.

In a series of statements posted on X, Khamenei said the renewed U.S. military operations provided “yet another indisputable testament to the US’s dishonesty, irrationality, unreliability, and malicious nature.” He warned that Tehran would respond with “unforgettable lessons” for what he called the “American enemy.”

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“Now that the American enemy is seeking to escalate the conflict thereby incurring even heavier costs and further humiliation, it should know that the noble nation of Iran and the Resistance Front have unforgettable lessons in store for it,” Khamenei wrote.

The Supreme Leader has not appeared in public since succeeding his father, slain Ayatollah Ali Khamenei, in the early days of the conflict. Defense Secretary Pete Hegseth told reporters in March that Khamenei was “wounded and likely disfigured” from the Feb. 28 strike on his father’s compound.

One of Khamenei’s senior advisers, Major-General Mohsen Rezaei, threatened on Friday to resume “full-scale offensive operations” against U.S. forces and allies, declaring that “no political border will be safe” unless the American military campaign stops.

U.S. Central Command said late Friday that American forces had struck “surveillance sites, military logistics infrastructure, underground weapons storage, and maritime capabilities,” and that a naval blockade in the Strait of Hormuz was again being fully enforced. In a major escalation, Iran launched retaliatory missile and drone strikes targeting U.S. facilities in neighboring Gulf countries, including Jordan, Kuwait and Bahrain. Centcom confirmed Saturday that two U.S. service members were killed while defending against Iranian attacks in Jordan on Friday, and another service member is missing in action. Their identities have not yet been released. Read more about the two US troops killed in Jordan as Trump expands Iran strikes.

Iran’s Deputy Foreign Minister Kazem Gharibabadi announced that Tehran has suspended its commitments under the 60-day ceasefire agreement, citing what he described as “aggressive actions” by the United States. “The United States has effectively trampled all of its commitments and suspended them,” Gharibabadi told Iran International. “We have also suspended our commitments under the Islamabad memorandum of understanding and are not implementing them.”

The collapse of the ceasefire comes as negotiators had been struggling to maintain momentum amid a flare-up of tit-for-tat strikes in recent weeks. Trump, in an interview with Fox News on Tuesday, made clear he was not interested in returning to talks. “I don’t want to negotiate now,” he said. “They want to make a deal, but every time they make a deal, they break it.”

The U.S. has also expanded its strikes against Iranian targets in recent days, part of a broader military campaign that Trump has linked to domestic political messaging. For more on the political backdrop, see how U.S. expands Iran strikes as Trump revives election fraud claims. Meanwhile, the administration’s aggressive posture has drawn scrutiny from critics who argue it risks a wider regional war.